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MedKoo Biosciences/Dovitinib lactate/200760/2g

🕔 2020-11-02

Dovitinib, also known as TKI-258 or CHIR-258, is an orally bioavailable FGFR3 inhibitor, which strongly binds to fibroblast growth factor receptor 3 (FGFR3) and inhibits its phosphorylation, which may result in the inhibition of tumor cell proliferation a全文>>

MedKoo Biosciences/Mahanine/406297/2g

🕔 2020-11-12

Mahanine, a carbazole alkaloid (occurs in the edible part of Micromelum minutum, Murraya koenigii and related species), is a DNA minor groove binding agent with potent anticancer activity. Mahanine down regulates cell survival factors by activation of cas全文>>

MedKoo Biosciences/CH223191/406631/10mg

🕔 2021-03-15

CH223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. CH223191 can prevent 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollut全文>>

MedKoo Biosciences/HAC-Y6/406509/100mg

🕔 2021-04-01

HAC-Y6 is a novel and potent microtubule inhitor. HAC-Y60 exhibited potent antitumor activity against human hepatocellular carcinoma (HCC) cells in vitro. Western blot and immunofluorescence experiments showed that HAC-Y6 depolymerized microtubules simila全文>>

MedKoo Biosciences/SNX-2112/205736/200mg

🕔 2021-04-15

SNX-2112, also known as PF 04928473, is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials. In all cell lines, SNX-2112 led to degradation of MET, HER-2, EGFR, and AKT as well as abrogation of Ras/Raf/MEK/MAPK and PI3K/AKT s全文>>

MedKoo Biosciences/Sofosbuvir/314202/200mg

🕔 2021-04-24

Sofosbuvir, also known as PSI-7977 and GS7977 (brand names Sovaldi and Virunon), is a drug used for hepatitis C virus (HCV) infection, with a high cure rate. It inhibits the RNA polymerase that the hepatitis C virus uses to replicate its RNA. It was disco全文>>

MedKoo Biosciences/Osimertinib free base/206042/100g

🕔 2021-05-21

Osimertinib, also known as AZD-9291 and Mereletinib, is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is h全文>>

MedKoo Biosciences/MG-132/406304/2g

🕔 2024-03-07

MG132 is a specific, potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM) . It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or全文>>

MedKoo Biosciences/HJC-0123/406528/50mg

🕔 2016-03-06

Downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. Furthermore, HJC-0123 significant全文>>

MedKoo Biosciences/Laniquidar/205879/100mg

🕔 2016-03-10

Laniquidar is a third-generation P-gp inhibitor, which has been used in clinic trials for modulating multidrug resistance transporters. A study of docetaxel in combination with the new orally administered P-glycoprotein (P-gp) inhibitor R101933 showed tha全文>>

热卖商品

MedKoo Biosciences/RX-3117/206092/100mg

MedKoo Biosciences/RX-3117/206092/100mg

MedKoo Biosciences/Tenofovir alafenamide fumarate (1:1 salt)/314271/20g

MedKoo Biosciences/Tenofovir alafenamide fumarate (1:1 salt)/314271/20g

MedKoo Biosciences/JNJ-38877605/201615/10mg

MedKoo Biosciences/JNJ-38877605/201615/10mg

MedKoo Biosciences/Talazoparib/204710/500mg

MedKoo Biosciences/Talazoparib/204710/500mg

公司介绍

MedKoo 美帝药库公司以药物化学合成技术为核心，密切结合全球抗癌新药研发领域中的新技术、新理论、新趋势和新的发展方向，不断推出抗癌化合物新品种。。美帝药库MedKoo将在中国建立药物化学合成生产基地和多个现代化药物化合物存储仓库。美帝药库的药物化合物来源于以下几个渠道：自主合成、委托化学合成、合作伙伴、和从国内外市场上选购。 MedKo

品牌分类

转化生长因子β/Smad Angiogenesis DNA损伤 Apoptosis 内分泌与激素细胞周期

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