Synonym:CCG1423;CCG-1423;CCG1423.

IUPAC/ChemicalName:N-((1-((4-chlorophenyl)amino)-1-oxopropan-2-yl)oxy)-3,5-bis(trifluoromethyl)benzamide

InChiKey:DSMXVSGJIDFLKP-UHFFFAOYSA-N

InChiCode:InChI=1S/C18H13ClF6N2O3/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25/h2-9H,1H3,(H,26,28)(H,27,29)

SMILESCode:O=C(NOC(C)C(NC1=CC=C(Cl)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

TechnicalData

AdditionalInformation

References

1:HayashiK,WatanabeB,NakagawaY,MinamiS,MoritaT.RPELproteinsarethemoleculartargetsforCCG-1423,aninhibitorofRhosignaling.PLoSOne.2014Feb18;9(2):e89016.doi:10.1371/journal.pone.0089016.eCollection2014.PubMedPMID:24558465;PubMedCentralPMCID:PMC3928398.

2:BellJL,HaakAJ,WadeSM,SunY,NeubigRR,LarsenSD.Designandsynthesisoftag-freephotoprobesfortheidentificationofthemoleculartargetforCCG-1423,anovelinhibitoroftheRho/MKL1/SRFsignalingpathway.BeilsteinJOrgChem.2013May21;9:966-73.doi:10.3762/bjoc.9.111.Print2013.PubMedPMID:23766813;PubMedCentralPMCID:PMC3678708.

3:EvelynCR,BellJL,RyuJG,WadeSM,KocabA,HarzdorfNL,ShowalterHD,NeubigRR,LarsenSD.Design,synthesisandprostatecancercell-basedstudiesofanalogsoftheRho/MKL1transcriptionalpathwayinhibitor,CCG-1423.BioorgMedChemLett.2010Jan15;20(2):665-72.doi:10.1016/j.bmcl.2009.11.056.Epub2009Nov18.PubMedPMID:19963382;PubMedCentralPMCID:PMC2818594.

4:EvelynCR,WadeSM,WangQ,WuM,Iñiguez-LluhíJA,MerajverSD,NeubigRR.CCG-1423:asmall-moleculeinhibitorofRhoAtranscriptionalsignaling.MolCancerTher.2007Aug;6(8):2249-60.PubMedPMID:17699722.