AC17
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406291
CAS#:51460-26-5
Description:AC17, a novel 4-arylidene curcumin analog, is a potent 19S deubiquitinase inhibitors with great potential for anticancer drug development. AC17 serves as an irreversible deubiquitinase inhibitor of 19S RP, resulting in inhibition of NF-κB pathway and reactivation of proapoptotic protein p53. In addition, in a murine xenograft model of human lung cancer A549, treatment with AC17 suppresses tumor growth in a manner associated with proteasome inhibition, NF-κB blockage, and p53 reactivation.
Price and Availability
AC17, purity > 98%, is not in stock, may be available through custom synthesis. Minimum 1 gram order is requested. Current shipping out time is about 70 days after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406291Name: AC17CAS#: 51460-26-5Chemical Formula: C31H30O8Exact Mass: 530.19407Molecular Weight: 530.57Elemental Analysis: C, 70.18; H, 5.70; O, 24.12
Synonym:AC17; 4arylidene curcumin;
IUPAC/Chemical Name:(1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-(4-hydroxy-3-methoxybenzylidene)hepta-1,6-diene-3,5-dione
InChi Key:AYIYVEPNEPUJCF-GNXRPPCSSA-N
InChi Code:InChI=1S/C31H30O8/c1-35-27-14-9-20(17-30(27)38-4)6-11-24(32)23(16-22-8-13-26(34)29(19-22)37-3)25(33)12-7-21-10-15-28(36-2)31(18-21)39-5/h6-19,34H,1-5H3/b11-6+,12-7+
SMILES Code:O=C(/C(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)=C/C2=CC=C(O)C(OC)=C2)/C=C/C3=CC=C(OC)C(OC)=C3
Technical Data
Additional Information
References
1: Zhou B, Zuo Y, Li B, Wang H, Liu H, Wang X, Qiu X,Hu Y, Wen S, Du J, Bu X. Deubiquitinase Inhibition of 19S Regulatory Particles by 4-ArylideneCurcumin Analog AC17 Causes NF-κB Inhibition and p53 Reactivation in Human LungCancer Cells. Mol Cancer Ther. 2013 Aug;12(8):1381-92. doi: 10.1158/1535-7163.MCT-12-1057. Epub 2013 May 21. PubMed PMID: 23696216.
