RO-3306

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WARNING: This product is for research use only, not for human or veterinary use.

Description:RO-3306 is a CDK1 inhibitor with potential anticancer activity. Treatment of growing AML cells with RO-3306 induced G2/M-phase cell cycle arrest and apoptosis in a dose- and time-dependent manner. RO-3306 downregulated expression of the antiapoptotic proteins Bcl-2 and survivin and blocked p53-mediated induction of p21 and MDM2. RO-3306 actively enhances downstream p53 signaling to promote apoptosis.

Price and Availability

RO-3306, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406182Name: RO-3306CAS#: 872573-93-8Chemical Formula: C18H13N3OS2Exact Mass: 351.05Molecular Weight: 351.44Elemental Analysis: C, 61.52; H, 3.73; N, 11.96; O, 4.55; S, 18.24

Synonym:RO3306; RO 3306; RO-3306

IUPAC/Chemical Name:5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

InChi Key:XOLMRFUGOINFDQ-MHWRWJLKSA-N

InChi Code:InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10+

SMILES Code:O=C1N=C(NCC2=CC=CS2)S/C1=C/C3=CC=C4N=CC=CC4=C3

Technical Data

Additional Information

References

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