
Inauhzinfeatured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406518
CAS#:309271-94-1
Description:Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice.
Price and Availability
Inauhzin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure

Theoretical Analysis
MedKoo Cat#: 406518Name: InauhzinCAS#: 309271-94-1Chemical Formula: C25H19N5OS2Exact Mass: 469.1031Molecular Weight: 469.58Elemental Analysis: C, 63.94; H, 4.08; N, 14.91; O, 3.41; S, 13.66
Synonym:Inauhzin
IUPAC/Chemical Name:2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one
InChi Key:VHUOXERIKQWIJE-UHFFFAOYSA-N
InChi Code:InChI=1S/C25H19N5OS2/c1-2-19(33-25-27-23-22(28-29-25)15-9-3-4-10-16(15)26-23)24(31)30-17-11-5-7-13-20(17)32-21-14-8-6-12-18(21)30/h3-14,19H,2H2,1H3,(H,26,27,29)
SMILES Code:CCC(SC1=NN=C2C(NC3=C2C=CC=C3)=N1)C(N4C5=C(C=CC=C5)SC6=CC=CC=C46)=O
Technical Data
Additional Information
References
1: Zhang Y, Zhang Q, Zeng SX, Hao Q, Lu H. Inauhzinsensitizes p53-dependent cytotoxicity and tumor suppression ofchemotherapeutic agents. Neoplasia. 2013 May;15(5):523-34. PubMed PMID:23633924; PubMed Central PMCID: PMC3638355.
2: Liao JM, Zeng SX, Zhou X, Lu H. Global effect of inauhzin on humanp53-responsive transcriptome. PLoS One. 2012;7(12):e52172. doi:10.1371/journal.pone.0052172. Epub 2012 Dec 21. PubMed PMID: 23284922;PubMed Central PMCID: PMC3528779.
3: Zhang Q, Ding D, Zeng SX, Ye QZ, Lu H. Structure and activityanalysis of Inauhzin analogs as novel antitumor compounds that inducep53 and inhibit cell growth. PLoS One. 2012;7(10):e46294. doi:10.1371/journal.pone.0046294. Epub 2012 Oct 24. PubMed PMID: 23115626;PubMed Central PMCID: PMC3480348.
4: Zhang Y, Zhang Q, Zeng SX, Zhang Y, Mayo LD, Lu H. Inauhzin andNutlin3 synergistically activate p53 and suppress tumor growth. CancerBiol Ther. 2012 Aug;13(10):915-24. doi: 10.4161/cbt.20844. Epub 2012 Aug1. PubMed PMID: 22785205; PubMed Central PMCID: PMC3414413.
5: Zhang Q, Zeng SX, Zhang Y, Zhang Y, Ding D, Ye Q, Meroueh SO, Lu H. Asmall molecule Inauhzin inhibits SIRT1 activity and suppresses tumourgrowth through activation of p53. EMBO Mol Med. 2012 Apr;4(4):298-312.doi: 10.1002/emmm.201100211. Epub 2012 Feb 13. PubMed PMID: 22331558;PubMed Central PMCID: PMC3376857.