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商品详细MedKoo/Inuhzin/100mg/406518
MedKoo/Inuhzin/100mg/406518
MedKoo/Inuhzin/100mg/406518
商品编号: 406518
品牌: MedKoo
市场价: ¥19000.00
美元价: 11400.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Inauhzin
featured

WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#:406518

CAS#:309271-94-1

Description:Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice.

Price and Availability

SizePriceShipping out timeQuantity
100mgUSD 9502 Weeks
200mgUSD 16502 Weeks
500mgUSD 26502 Weeks
1gUSD 37502 Weeks
2gUSD 54502 Weeks
5gUSD 86502 Weeks
Inquire bulk and customized quantity

Pricing updated 2021-01-23.Prices are subject to change without notice.

Inauhzin, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406518Name: InauhzinCAS#: 309271-94-1Chemical Formula: C25H19N5OS2Exact Mass: 469.1031Molecular Weight: 469.58Elemental Analysis: C, 63.94; H, 4.08; N, 14.91; O, 3.41; S, 13.66

Synonym:Inauhzin

IUPAC/Chemical Name:2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one

InChi Key:VHUOXERIKQWIJE-UHFFFAOYSA-N

InChi Code:InChI=1S/C25H19N5OS2/c1-2-19(33-25-27-23-22(28-29-25)15-9-3-4-10-16(15)26-23)24(31)30-17-11-5-7-13-20(17)32-21-14-8-6-12-18(21)30/h3-14,19H,2H2,1H3,(H,26,27,29)

SMILES Code:CCC(SC1=NN=C2C(NC3=C2C=CC=C3)=N1)C(N4C5=C(C=CC=C5)SC6=CC=CC=C46)=O

Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001

Additional Information

References

1: Zhang Y, Zhang Q, Zeng SX, Hao Q, Lu H. Inauhzinsensitizes p53-dependent cytotoxicity and tumor suppression ofchemotherapeutic agents. Neoplasia. 2013 May;15(5):523-34. PubMed PMID:23633924; PubMed Central PMCID: PMC3638355.

2: Liao JM, Zeng SX, Zhou X, Lu H. Global effect of inauhzin on humanp53-responsive transcriptome. PLoS One. 2012;7(12):e52172. doi:10.1371/journal.pone.0052172. Epub 2012 Dec 21. PubMed PMID: 23284922;PubMed Central PMCID: PMC3528779.

3: Zhang Q, Ding D, Zeng SX, Ye QZ, Lu H. Structure and activityanalysis of Inauhzin analogs as novel antitumor compounds that inducep53 and inhibit cell growth. PLoS One. 2012;7(10):e46294. doi:10.1371/journal.pone.0046294. Epub 2012 Oct 24. PubMed PMID: 23115626;PubMed Central PMCID: PMC3480348.

4: Zhang Y, Zhang Q, Zeng SX, Zhang Y, Mayo LD, Lu H. Inauhzin andNutlin3 synergistically activate p53 and suppress tumor growth. CancerBiol Ther. 2012 Aug;13(10):915-24. doi: 10.4161/cbt.20844. Epub 2012 Aug1. PubMed PMID: 22785205; PubMed Central PMCID: PMC3414413.

5: Zhang Q, Zeng SX, Zhang Y, Zhang Y, Ding D, Ye Q, Meroueh SO, Lu H. Asmall molecule Inauhzin inhibits SIRT1 activity and suppresses tumourgrowth through activation of p53. EMBO Mol Med. 2012 Apr;4(4):298-312.doi: 10.1002/emmm.201100211. Epub 2012 Feb 13. PubMed PMID: 22331558;PubMed Central PMCID: PMC3376857.

品牌介绍
MedKoo 美帝药库公司以药物化学合成技术为核心,密切结合全球抗癌新药研发领域中的新技术、新理论、新趋势和新的发展方向,不断推出抗癌化合物新品种。 。 美帝药库MedKoo将在中国建立药物化学合成生产基地和多个现代化药物化合物存储仓库。 美帝药库的药物化合物来源于以下几个渠道:自主合成、委托化学合成、合作伙伴、和从国内外市场上选购。 MedKoo美帝药库的抗癌分子库 MedKoo的目标是打造全球规模最大、品种最多、类别最全和质量最好的小分子抗癌化合物库。MedKoo的抗癌药库将由下列5个分子库组成: (1)上市抗癌药库:该库将含有大约100个全球已批准上市的小分子抗癌化合物; (2)抗癌候选药物库:该分子库含有大约400个世界各国正在临床研究中抗癌小分子候选药物; (3)同系抗癌分子库:该分子库将含有多个化学结构类似或抗癌机制类似的分子包; (4)抗癌分子预制模块库:该库主要含有用于组建抗癌目标分子的分子模块包; (5)同位素标记抗癌分子库。