BML-258 HCl
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406472
CAS#:1072443-89-0
Description:BML-258 HCl was removedand discontinued.
Price and Availability
BML258 HCl was discontinued.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406472Name: BML-258 HClCAS#: 1072443-89-0Chemical Formula: C17H28ClNO2Exact Mass: Molecular Weight: 313.86272Elemental Analysis: C, 65.05; H, 8.99; Cl, 11.30; N, 4.46; O, 10.20
Synonym:BML258; BML 258; BML-258; SK1I.
IUPAC/Chemical Name:(2R,3S,E)-2-(methylamino)-5-(4-pentylphenyl)pent-4-ene-1,3-diol hydrochloride
InChi Key:SGCJOKUPGVFNKS-UUCPMUBFSA-N
InChi Code:InChI=1S/C17H27NO2.ClH/c1-3-4-5-6-14-7-9-15(10-8-14)11-12-17(20)16(13-19)18-2;/h7-12,16-20H,3-6,13H2,1-2H3;1H/b12-11+;/t16-,17+;/m1./s1
SMILES Code:OC[C@@H](NC)[C@@H](O)/C=C/C1=CC=C(CCCCC)C=C1.[H]Cl
Technical Data
Additional Information
References
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2: Nagahashi M, Ramachandran S, Kim EY, Allegood JC, Rashid OM, YamadaA, Zhao R, Milstien S, Zhou H, Spiegel S, Takabe K.Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breastcancer progression by stimulating angiogenesis and lymphangiogenesis.Cancer Res. 2012 Feb 1;72(3):726-35. doi: 10.1158/0008-5472.CAN-11-2167.PubMed PMID: 22298596; PubMed Central PMCID: PMC3289261.
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4: Kapitonov D, Allegood JC, Mitchell C, Hait NC, Almenara JA, Adams JK,Zipkin RE, Dent P, Kordula T, Milstien S, Spiegel S. Targetingsphingosine kinase 1 inhibits Akt signaling, induces apoptosis, andsuppresses growth of human glioblastoma cells and xenografts. CancerRes. 2009 Sep 1;69(17):6915-23. doi: 10.1158/0008-5472.CAN-09-0664.PubMed PMID: 19723667; PubMed Central PMCID: PMC2752891.
5: Paugh SW, Paugh BS, Rahmani M, Kapitonov D, Almenara JA, Kordula T,Milstien S, Adams JK, Zipkin RE, Grant S, Spiegel S. A selectivesphingosine kinase 1 inhibitor integrates multiple molecular therapeutictargets in human leukemia. Blood. 2008 Aug 15;112(4):1382-91. doi:10.1182/blood-2008-02-138958. Epub 2008 May 29. PubMed PMID: 18511810;PubMed Central PMCID: PMC2515133.
