CEP-11981

WARNING: This product is for research use only, not for human or veterinary use.

Description:CEP-11981 is an orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death.

Price and Availability

CEP-11981 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 200712Name: CEP-11981CAS#: 856691-93-5Chemical Formula: C28H27N7OExact Mass: 477.22771Molecular Weight: 477.56Elemental Analysis: C, 70.42; H, 5.70; N, 20.53; O, 3.35

Synonym:CEP11981; CEP 11981; CEP11981

IUPAC/Chemical Name:13-isobutyl-4-methyl-10-(pyrimidin-2-ylamino)-4,7,8,13-tetrahydro-1H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-6(2H)-one

InChi Key:AEULIVPVIDOLIN-UHFFFAOYSA-N

InChi Code:InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)

SMILES Code:O=C1NCC2=C1C(C3=CN(C)N=C3CC4)=C4C(N5CC(C)C)=C2C6=C5C=CC(NC7=NC=CC=N7)=C6

Technical Data

Additional Information

References

1: Hudkins RL, Becknell NC, Zulli AL, Underiner TL,Angeles TS, Aimone LD, Albom  MS, Chang H, Miknyoczki SJ, Hunter K,Jones-Bolin S, Zhao H, Bacon ER, Mallamo JP, Ator MA, Ruggeri BA.Synthesis and biological profile of the pan-vascular endothelial growthfactor receptor/tyrosine kinase with immunoglobulin and epidermal growthfactor-like homology domains 2 (VEGF-R/TIE-2) inhibitor 11-(2-methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one(CEP-11981): a novel oncology therapeutic agent. J Med Chem. 2012 Jan26;55(2):903-13. doi: 10.1021/jm201449n. Epub 2012 Jan 6. Erratum in: JMed Chem. 2012 Apr 26;55(8):4025. PubMed PMID: 22148921.