Cediranib free basefeatured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:200690
CAS#:288383-20-0 (free base)
Description:Cediranib, also known as AZD-2171, is a potent and selective VEGF inhibitor with antineoplastic activities. Competing with adenosine triphosphate, cediranib binds to and inhibits all three vascular endothelial growth factor receptor (VEGF-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.
Price and Availability
Cediranib free base,purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 200690Name: Cediranib free baseCAS#: 288383-20-0 (free base)Chemical Formula: C25H27FN4O3Exact Mass: 450.20672Molecular Weight: 450.5Elemental Analysis: C, 66.65; H, 6.04; F, 4.22; N, 12.44; O, 10.65.
Related CAS #:857036-77-2 (maleate)288383-20-0 (free base)
Synonym:AZD2171; AZD 2171; AZD-2171; AZD2171 free base; Cediranib;brand name: Recentin.
IUPAC/Chemical Name:4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline
InChi Key:XXJWYDDUDKYVKI-UHFFFAOYSA-N
InChi Code:InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3
SMILES Code:COC1=CC2=C(OC3=C(F)C4=C(NC(C)=C4)C=C3)N=CN=C2C=C1OCCCN5CCCC5
Technical Data
Additional Information
According to http://en.wikipedia.org/wiki/Cediranib, Cediranib is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases. It is being developed by AstraZeneca as a possible anti-cancer chemotherapeutic agent for oral administration. Beginning in 2007, it is undergoing Phase I clinical trials for the treatment of non-small cell lung cancer, kidney cancer, and colorectal cancer in adults, as well as tumors of the central nervous system in children. Phase I trials of interactions with other drugs used in cancer treatment are also underway. On February 27, 2008, AstraZeneca announced that the use of Recentin in non-small cell lung cancer will not progress into phase III after failing to meet its main goal. On 8th March 2010, AstraZeneca issued a press-release stating that Recentin had failed Phase III clinical trials for use in first-line metastatic colorectal cancer when it was compared clinically with the market-leader Avastin.
References
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