STA-9584
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:206189
CAS#:906481-23-0
Description:STA-9584 is a potent vascular disrupting agent, which exhibits potent antitumor activity by selectively targeting microvasculature at both the center and periphery of tumors. In vitro, 2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)aniline (STA-9122) (active metabolite of STA-9584 ) displayed increased potency relative to other tubulin-binding agents and was highly cytotoxic to tumor cells. STA-9584 induced significant tumor regressions in prostate and breast xenograft models in vivo and, in an aggressive syngeneic model, demonstrated superior tumor growth inhibition and a positive therapeutic index relative to combretastatin A-4 phosphate (CA4P).
Price and Availability
STA-9584 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 206189Name: STA-9584CAS#: 906481-23-0Chemical Formula: C28H29N3O6Exact Mass: 503.20564Molecular Weight: 503.55Elemental Analysis: C, 66.79; H, 5.80; N, 8.34; O, 19.06
Synonym:STA9584; STA 9584; STA9584.
IUPAC/Chemical Name:(S)-2-amino-N-(2-methoxy-5-(5-(3,4,5-trimethoxyphenyl)isoxazol-4-yl)phenyl)-3-phenylpropanamide hydrochloride
InChi Key:DPEXZURXDJIYRS-BOXHHOBZSA-N
InChi Code:InChI=1S/C28H29N3O6.ClH/c1-33-23-11-10-18(13-22(23)31-28(32)21(29)12-17-8-6-5-7-9-17)20-16-30-37-26(20)19-14-24(34-2)27(36-4)25(15-19)35-3;/h5-11,13-16,21H,12,29H2,1-4H3,(H,31,32);1H/t21-;/m0./s1
SMILES Code:O=C(NC1=CC(C2=C(C3=CC(OC)=C(OC)C(OC)=C3)ON=C2)=CC=C1OC)[C@@H](N)CC4=CC=CC=C4.[H]Cl
Technical Data
Additional Information
References
1: Foley KP, Zhou D, Borella C, Wu Y, Zhang M, JiangJ, Li H, Sang J, Korbut T, Ye J, Zhang X, Barsoum J, Sonderfan AJ. Thevascular disrupting agent STA-9584 exhibits potent antitumor activity byselectively targeting microvasculature at both the center and peripheryof tumors. J Pharmacol Exp Ther. 2012 Nov;343(2):529-38. doi:10.1124/jpet.112.196873. Epub 2012 Jul 26. PubMed PMID: 22837008.
