M410

WARNING: This product is for research use only, not for human or veterinary use.

Description:M410 is a vascular disrupting agent, which showed potent cytotoxic activity toward proliferating tumor cells and exhibited a similar cytotoxicity against multi-drug resistant (MDR) tumor cells. M410 inhibited bovine brain tubulin polymerization in a way similar to that of colchicine. In proliferating human umbilical vein endothelial cells (HUVECs), 20 nM of M410 induced cellular tubulin depolymerization within 4 h, which led to M phase arrest. M410 is a potent microtubule inhibitor that is cytotoxic, angiogenesis inhibiting and vascular targeting.

Price and Availability

M410 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406315Name: M410CAS#: unknown Chemical Formula: C17H17Na2O7PExact Mass: Molecular Weight: 410.27Elemental Analysis: C, 49.77; H, 4.18; Na, 11.21; O, 27.30; P, 7.55

Synonym:M410; M-410; M 410.

IUPAC/Chemical Name:sodium (Z)-5-(3,5-dimethoxystyryl)-2-methoxyphenyl phosphate

InChi Key:IITOLTJSTUDQOB-WNCVTPEDSA-L

InChi Code:InChI=1S/C17H19O7P.2Na/c1-21-14-8-13(9-15(11-14)22-2)5-4-12-6-7-16(23-3)17(10-12)24-25(18,19)20;;/h4-11H,1-3H3,(H2,18,19,20);;/q;2*+1/p-2/b5-4-;;

SMILES Code:O=P([O-])([O-])OC1=CC(/C=CC2=CC(OC)=CC(OC)=C2)=CC=C1OC.[Na+].[Na+]

Technical Data

Additional Information

References

1: Cai YC, Zou Y, Ye YL, Sun HY, Su QG, Wang ZX, ZengZL, Xian LJ. Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4",5-trimethoxylstilbene-3"-O-phosphate disodium (M410). InvestNew Drugs.2011 Apr;29(2):300-11. doi: 10.1007/s10637-009-9366-x. Epub 2009 Dec 11.PubMed PMID: 20012336.