CCT196969featured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406645
CAS#:1163719-56-9
Description:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT196969 blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEK–ERK, in vitro and in vivo. CCT196969 also prevented growth of xenografts derived from patient tumours with acquired or intrinsic resistance to BRAF and MEK inhibitors. BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs.
Price and Availability
CCT196969, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406645Name: CCT196969CAS#: 1163719-56-9Chemical Formula: C27H24FN7O3Exact Mass: 513.19247Molecular Weight: 513.52Elemental Analysis: C, 63.15; H, 4.71; F, 3.70; N, 19.09; O, 9.35
Synonym:CCT196969; CCT-196969; CCT 196969.
IUPAC/Chemical Name:1-(3-(tert-butyl)-1-phenyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
InChi Key:KYYKGSDLXXKQCR-UHFFFAOYSA-N
InChi Code:InChI=1S/C27H24FN7O3/c1-27(2,3)21-14-22(35(34-21)16-7-5-4-6-8-16)32-26(37)31-19-10-9-17(13-18(19)28)38-20-11-12-29-25-24(20)30-15-23(36)33-25/h4-15H,1-3H3,(H,29,33,36)(H2,31,32,37)
SMILES Code:FC1=CC(OC2=C3C(NC(C=N3)=O)=NC=C2)=CC=C1NC(NC4=CC(C(C)(C)C)=NN4C5=CC=CC=C5)=O
Technical Data
Additional Information
References
1: Girotti MR, Lopes F, Preece N, Niculescu-Duvaz D,Zambon A, Davies L, Whittaker S, Saturno G, Viros A, Pedersen M, Suijkerbuijk BM, Menard D,McLeary R, Johnson L, Fish L, Ejiama S, Sanchez-Laorden B, Hohloch J, CarragherN, Macleod K, Ashton G, Marusiak AA, Fusi A, Brognard J, Frame M, LoriganP, MaraisR, Springer C. Paradox-breaking RAF inhibitors that also target SRC areeffective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015 Jan12;27(1):85-96. doi: 10.1016/j.ccell.2014.11.006. Epub 2014 Dec 11. PubMed PMID:25500121; PubMed Central PMCID: PMC4297292.
