AZD-0424

WARNING: This product is for research use only, not for human or veterinary use.

Description:AZD-0424 is an orally bioavailable small molecule tyrosine kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Upon oral administration, AZD0424 selectively inhibits both Src and Abl kinase activity which may result in the inhibition of tumor growth in susceptible tumor cells. Src and Abl kinases are upregulated in certain tumor cells and play important roles in tumor cell proliferation and metastasis.

Price and Availability

AZD-0424, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 205948Name: AZD-0424CAS#:692054-06-1Chemical Formula: C25H29ClN6O5Exact Mass: 528.1888Molecular Weight: 528.994Elemental Analysis: C, 56.76; H, 5.53; Cl, 6.70; N, 15.89; O, 15.12

Synonym:AZD0424; AZD 0424; AZD-0424

IUPAC/Chemical Name:1-(4-(2-((4-((6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino)-5-isopropoxyquinazolin-7-yl)oxy)ethyl)piperazin-1-yl)ethan-1-one

InChi Key:MVWATCATLSSVBH-UHFFFAOYSA-N

InChi Code:InChI=1S/C25H29ClN6O5/c1-15(2)37-20-11-17(34-9-8-31-4-6-32(7-5-31)16(3)33)10-19-21(20)24(29-13-28-19)30-22-18(26)12-27-25-23(22)35-14-36-25/h10-13,15H,4-9,14H2,1-3H3,(H,27,28,29,30)

SMILES Code:CC(C)OC1=C2C(N=CN=C2NC3=C(OCO4)C4=NC=C3Cl)=CC(OCCN5CCN(C(C)=O)CC5)=C1

Technical Data

Additional Information

References

1: Nowak D, Boehrer S, Hochmuth S, Trepohl B, HofmannW, Hoelzer D, Hofmann WK, Mitrou PS, Ruthardt M, Chow KU. Src kinase inhibitors induce apoptosisand mediate cell cycle arrest in lymphoma cells. Anticancer Drugs. 2007 Oct;18(9):981-95. PubMed PMID: 17704648.