Henatinib
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:205845
CAS#:1239269-51-2
Description:Henatinib maleate is t he maleate salt form of henatinib, an orally bioavalable, multitargeted tyrosine kinase inhibitor with potential antitumor and antiangiogenic activities. Henatinib inhibits vascular endothelial growth factor receptor type 2 (VEGFR2), a tyrosine kinase receptor upregulated in many tumor cells that plays a key role in angiogenesis. This may result in an inhibition of angiogenesis and eventually tumor cell proliferation. Henatinib, structurally similar to sunitinib, also inhibits, though to a lesser extent, mast/stem cell growth factor receptor (c-Kit) and, platelet-derived growth factor receptor (PDGFR) alpha and beta. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).
Price and Availability
Henatinib is not in stock, but is available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 205845Name: HenatinibCAS#: 1239269-51-2Chemical Formula: C25H29FN4O4Exact Mass: 468.21728Molecular Weight: 468.52056Elemental Analysis:C, 64.09; H, 6.24; F, 4.05; N, 11.96; O, 13.66
Synonym:Henatinib
IUPAC/Chemical Name:(R,Z)-2-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-5-(2-hydroxy-3-morpholinopropyl)-3-methyl-5,6,7,8-tetrahydropyrrolo[3,2-c]azepin-4(1H)-one
InChi Key:MCTXSDCWFQAGFS-UEXNTNOUSA-N
InChi Code:InChI=1S/C25H29FN4O4/c1-15-22(12-19-18-11-16(26)4-5-20(18)28-24(19)32)27-21-3-2-6-30(25(33)23(15)21)14-17(31)13-29-7-9-34-10-8-29/h4-5,11-12,17,27,31H,2-3,6-10,13-14H2,1H3,(H,28,32)/b19-12-/t17-/m1/s1
SMILES Code:O=C1N(C[C@H](O)CN2CCOCC2)CCCC3=C1C(C)=C(/C=C4C(NC5=C4C=C(F)C=C5)=O)N3
Technical Data
Additional Information
References
1: Gu P, Ding Y, Sun D, Hang T, Liu W, Ding L.Quantification of henatinib maleate, a novel potent inhibitor of VEGFreceptors, in rat plasma by LC-MS/MS. Biomed Chromatogr. 2010Apr;24(4):420-5. PubMed PMID: 19662624.
