AAL-993featured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406287
CAS#:269390-77-4
Description:AAL-993 is a highly potent inhibitor of VEGFR-1 (IC50 =130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR-β (640nM), c-Kit (236nM) and CSF-1R (380nM).
Price and Availability
AAL-993, purity > 98%, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406287Name: AAL-993CAS#: 269390-77-4Chemical Formula: C20H16F3N3OExact Mass: 371.12455Molecular Weight: 371.36Elemental Analysis: C, 64.69; H, 4.34; F, 15.35; N, 11.32; O, 4.31
Synonym:AAL993; AAL 993; AA-L993.
IUPAC/Chemical Name:2-((pyridin-4-ylmethyl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide
InChi Key:BLAFVGLBBOPRLP-UHFFFAOYSA-N
InChi Code:InChI=1S/C20H16F3N3O/c21-20(22,23)15-4-3-5-16(12-15)26-19(27)17-6-1-2-7-18(17)25-13-14-8-10-24-11-9-14/h1-12,25H,13H2,(H,26,27)
SMILES Code:O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=CC=C2NCC3=CC=NC=C3
Technical Data
Additional Information
References
1: Ban HS, Uno M, Nakamura H. Suppression ofhypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Differentprofiles of AAL993 versus SU5416 and KRN633. Cancer Lett. 2010 Oct1;296(1):17-26. doi: 10.1016/j.canlet.2010.03.010. Epub 2010 Apr 7.PubMed PMID: 20378243.
2: Honda T, Tajima H, Kaneko Y, Ban M, Inaba T, Takeno Y, Okamoto K,Aono H. Conformation-activity relationship on novel 4-pyridylmethylthioderivatives with antiangiogenic activity. Bioorg Med Chem Lett. 2008 May1;18(9):2939-43. doi: 10.1016/j.bmcl.2008.03.068. Epub 2008 Mar 29.PubMed PMID: 18420406.
3: Manley PW, Bold G, Brüggen J, Fendrich G, Furet P, Mestan J, SchnellC, Stolz B, Meyer T, Meyhack B, Stark W, Strauss A, Wood J. Advances inthe structural biology, design and clinical development of VEGF-R kinaseinhibitors for the treatment of angiogenesis. Biochim Biophys Acta. 2004Mar 11;1697(1-2):17-27. Review. PubMed PMID: 15023347.
