Cerdulatinib free basefeatured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:206113
CAS#:1198300-79-6 (free base)
Description:Cerdulatinib, also known as PRT2070 and PRT062070, is a n ovel, oral, dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Cerdulatinib preferentially inhibited JAK1 and JAK3 dependent cytokine mediated signaling and functional responses in various cell types. IL2 mediated STAT5 Y694 was inhibited with an IC50 of 0.27μM, while IL4 mediated signaling to STAT6 Y641 and functional responses in B cells and monocytes, namely CD69, CD25, and CD23 up-regulation, were inhibited with IC50Â’s within the range of 0.11μM to 0.57μM. It is currently being studied in patients with genetically-defined hematologic cancers, as well as for patients who have failed therapy due to relapse or acquired mutations.
Price and Availability
Cerdulatinib (PRT2070; PRT062070), purity > 98%, is in stock. The same day shipping out after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 206113Name: Cerdulatinib free baseCAS#: 1198300-79-6 (free base)Chemical Formula: C20H27N7O3SExact Mass: 445.18961Molecular Weight: 445.54Elemental Analysis: C, 53.92; H, 6.11; N, 22.01; O, 10.77; S, 7.20
Related CAS #:1198300-79-6 (free base)1369761-01-2 (HCl)
Synonym:PRT2070; PRT-2070; PRT 2070; PRT062070; PRT 062070; PRT-062070; Cerdulatinib.
IUPAC/Chemical Name:4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide
InChi Key:BGLPECHZZQDNCD-UHFFFAOYSA-N
InChi Code:InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25)
SMILES Code:O=C(C1=CN=C(NC2=CC=C(N3CCN(S(=O)(CC)=O)CC3)C=C2)N=C1NC4CC4)N
Technical Data
Additional Information
References
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