BMS-911543featured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:205767
CAS#:1271022-90-2
Description:BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.
Price and Availability
BMS-911543, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 205767Name: BMS-911543CAS#: 1271022-90-2Chemical Formula: C23H28N8OExact Mass: 432.23861Molecular Weight: 432.52142Elemental Analysis:C, 63.87; H, 6.53; N, 25.91; O, 3.70
Synonym:BMS911543; BMS-911543; BMS 911543.
IUPAC/Chemical Name:N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide
InChi Key:JCINBYQJBYJGDM-UHFFFAOYSA-N
InChi Code:InChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27)
SMILES Code:O=C(C1=CC2=C(N(C)C=N3)C3=C(NC4=NN(C)C(C)=C4)N=C2N1CC)N(C5CC5)C6CC6
Technical Data
Additional Information
In vitro activity of BMS-911432: (Source: Leukemia. 2012 Feb;26(2):280-8.)
References
1: Purandare AV, McDevitt TM, Wan H, You D, PenhallowB, Han X, Vuppugalla R, Zhang Y, Ruepp SU, Trainor GL, Lombardo L,Pedicord D, Gottardis MM, Ross-Macdonald P, de Silva H, Hosbach J,Emanuel SL, Blat Y, Fitzpatrick E, Taylor TL, McIntyre KW, Michaud E,Mulligan C, Lee FY, Woolfson A, Lasho TL, Pardanani A, Tefferi A,Lorenzi MV. Characterization of BMS-911543, a functionally selectivesmall-molecule inhibitor of JAK2. Leukemia. 2012 Feb;26(2):280-8. doi:10.1038/leu.2011.292. Epub 2011 Oct 21. PubMed PMID: 22015772.
