AZ-960

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WARNING: This product is for research use only, not for human or veterinary use.

Description:AZ960 is a novel inhibitor of Jak2 kinase. AZ960 inhibits JAK2 kinase with a K(i) of 0.00045 microm in vitro and treatment of TEL-JAK2 driven Ba/F3 cells with AZ960 blocked STAT5 phosphorylation and potently inhibited cell proliferation (GI(50)=0.025 microm). AZ960 demonstrated selectivity for TEL-JAK2-driven STAT5 phosphorylation and cell proliferation when compared with cell lines driven by similar fusions of the other JAK kinase family members.

Price and Availability

AZ-960, purity > 98%, is in stock. Same day shipping out after order received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406191Name: AZ-960CAS#: 905586-69-8Chemical Formula: C18H16F2N6Exact Mass: 354.14045Molecular Weight: 354.36Elemental Analysis:C, 61.01; H, 4.55; F, 10.72; N, 23.72

Synonym:AZ960; AZ 960; AZ-960.

IUPAC/Chemical Name:(S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile

InChi Key:SUNXHXDJOIXABJ-NSHDSACASA-N

InChi Code:InChI=1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1

SMILES Code:N#CC1=C(N[C@H](C2=CC=C(F)C=C2)C)N=C(NC3=NNC(C)=C3)C(F)=C1

Technical Data

Additional Information

References

1: Ikezoe T, Kojima S, Furihata M, Yang J, NishiokaC, Takeuchi A, Isaka M, Koeffler HP, Yokoyama A. Expression of p-JAK2predicts clinical outcome and is a potential molecular target of acutemyelogenous leukemia. Int J Cancer. 2011 Nov 15;129(10):2512-21. doi:10.1002/ijc.25910. Epub 2011 Apr 8. PubMed PMID: 21207414.

2: Yang J, Ikezoe T, Nishioka C, Furihata M, Yokoyama A. AZ960, a novelJak2 inhibitor, induces growth arrest and apoptosis in adult T-cellleukemia cells. Mol Cancer Ther. 2010 Dec;9(12):3386-95. doi: 10.1158/1535-7163.MCT-10-0416. PubMed PMID: 21159615.

3: Gozgit JM, Bebernitz G, Patil P, Ye M, Parmentier J, Wu J, Su N, WangT, Ioannidis S, Davies A, Huszar D, Zinda M. Effects of the JAK2inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283(47):32334-43. doi:10.1074/jbc.M803813200. Epub 2008 Sep 4. PubMed PMID: 18775810.