MPT0B098featured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406293
CAS#:1254363-89-7
Description:MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values ranging from 70 to 150 nmol/L. MPT0B098 arrests cells in the G2–M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. Distinguished from other microtubule inhibitors, MPT0B098 not only inhibited the expression levels of HIF-1α protein but also destabilized HIF-1α mRNA. The mechanism of causing unstable of HIF-1α mRNA by MPT0B098 is through decreasing RNA-binding protein, HuR, translocation from the nucleus to the cytoplasm. Notably, MPT0B098 effectively suppresses tumor growth and microvessel density of tumor specimens in vivo. Taken together, our results provide a novel mechanism of inhibiting HIF-1α of a microtubule inhibitor MPT0B098. MPT0B098 is a promising anticancer drug candidate with potential for the treatment of human malignancies. (source: Mol Cancer Ther; 2013, 12(7); 1202–12.
Price and Availability
MPT0B098, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406293Name: MPT0B098CAS#: 1254363-89-7Chemical Formula: C20H18N2O3SExact Mass: 366.10381Molecular Weight: 366.43Elemental Analysis: C, 65.55; H, 4.95; N, 7.64; O, 13.10; S, 8.75
Synonym:MPT0B098
IUPAC/Chemical Name:1-((4-methoxyphenyl)sulfonyl)-7-(pyridin-4-yl)indoline
InChi Key:AGYCYVPAEQVWJT-UHFFFAOYSA-N
InChi Code:InChI=1S/C20H18N2O3S/c1-25-17-5-7-18(8-6-17)26(23,24)22-14-11-16-3-2-4-19(20(16)22)15-9-12-21-13-10-15/h2-10,12-13H,11,14H2,1H3
SMILES Code:O=S(N1CCC2=C1C(C3=CC=NC=C3)=CC=C2)(C4=CC=C(OC)C=C4)=O
Technical Data
Additional Information
References
1: Cheng YC, Liou JP, Kuo CC, Lai WY, Shih KH, ChangCY, Pan WY, Tseng JT, Chang JY. MPT0B098, a Novel MicrotubuleInhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA throughDecreasing Nuclear-Cytoplasmic Translocation of RNA-Binding Protein HuR.Mol Cancer Ther. 2013 Jul;12(7):1202-12. doi:10.1158/1535-7163.MCT-12-0778. Epub 2013 Apr 25. PubMed PMID: 23619299.
