IOX 2featured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:401512
CAS#:931398-72-0
Description:IOX 2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) (IC50 = 21 nM). IOX 2 displays over 100-fold selectivity for PHD2 over factor inhibiting HIF-1 (FIH-1) and histone demethylases.
Price and Availability
IOX 2, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 401512Name: IOX 2CAS#: 931398-72-0Chemical Formula: C19H16N2O5Exact Mass: 352.10592Molecular Weight: 352.34Elemental Analysis: C, 64.77; H, 4.58; N, 7.95; O, 22.70
Synonym:IOX2; IOX-2; IOX 2
IUPAC/Chemical Name:N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
InChi Key:CAOSCCRYLYQBES-UHFFFAOYSA-N
InChi Code:InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
SMILES Code:O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O
Technical Data
Additional Information
References
1: Deppe J, Popp T, Egea V, Steinritz D, Schmidt A, Thiermann H, Weber C, Ries C.Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblastsby sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol.2015 Jun 17. [Epub ahead of print] PubMed PMID: 26082309.
2: Egert AM, Klotz JL, McLeod KR, Harmon DL. Development of a methodology tomeasure the effect of ergot alkaloids on forestomach motility using real-timewireless telemetry. Front Chem. 2014 Oct 13;2:90. doi: 10.3389/fchem.2014.00090. eCollection 2014. PubMed PMID: 25353021; PubMed Central PMCID: PMC4195290.
3: Sen A, Ren S, Lerchenmüller C, Sun J, Weiss N, Most P, Peppel K. MicroRNA-138 regulates hypoxia-induced endothelial cell dysfunction by targeting S100A1. PLoS One. 2013 Nov 11;8(11):e78684. doi: 10.1371/journal.pone.0078684. eCollection2013. Erratum in: PLoS One. 2013;8(12).doi:10.1371/annotation/53080a85-89cc-4a84-8fd9-0eb0c19cc05d. PLoS One. 2014;9(1).doi:10.1371/annotation/c7bddd8d-9f15-45f4-a886-740b351a39b6. PubMed PMID:24244340; PubMed Central PMCID: PMC3823839.
