CAY10585newfeatured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:401535
CAS#:934593-90-5
Description:CAY10585, also known as LW6, was first identified and reported by a group scientists from Korea. LW8 was found to inhibits the accumulation of HIF-1alpha. LW6 decreased HIF-1alpha protein expression without affecting HIF-1beta expression. It was further found that LW8 promoted the degradation of wild type HIF-1alpha, but not of a DM-HIF-1alpha with modifications of P402A and P564A, at hydroxylation sites in the oxygen-dependent degradation domain (ODDD). LW6 did not affect the activity of prolyl hydroxylase (PHD), but induced the expression of von Hippel-Lindau (VHL), which interacts with prolyl-hydroxylated HIF-1alpha for proteasomal degradation. In the presence of LW8, knockdown of VHL did not abolish HIF-1alpha protein accumulation, indicating that LW8 degraded HIF-1alpha via regulation of VHL expression. In mice carrying xenografts of human colon cancer HCT116 cells, LW8 demonstrated strong anti-tumor efficacy in vivo and caused a decrease in HIF-1alpha expression in frozen-tissue immunohistochemical staining. These data suggest that LW8 may be valuable in the development of a HIF-1alpha inhibitor for cancer treatment. (source: Biochem Pharmacol. 2010 Oct 1;80(7):982-9.)
Price and Availability
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Chemical Structure
Theoretical Analysis
MedKoo Cat#: 401535Name: CAY10585CAS#: 934593-90-5Chemical Formula: C26H29NO5Exact Mass: 435.20457Molecular Weight: 435.51216Elemental Analysis:C, 71.70; H, 6.71; N, 3.22; O, 18.37
Synonym:CAY10585; CAY-10585; CAY 10585; LW6; LW-6; LW 6
IUPAC/Chemical Name:methyl 3-(2-(4-(adamantan-1-yl)phenoxy)acetamido)-4-hydroxybenzoate
InChi Key:BJRPPNOJYFZSLY-UHFFFAOYSA-N
InChi Code:InChI=1S/C26H29NO5/c1-31-25(30)19-2-7-23(28)22(11-19)27-24(29)15-32-21-5-3-20(4-6-21)26-12-16-8-17(13-26)10-18(9-16)14-26/h2-7,11,16-18,28H,8-10,12-15H2,1H3,(H,27,29)
SMILES Code:O=C(OC)C1=CC=C(O)C(NC(COC2=CC=C(C34CC5CC(C4)CC(C5)C3)C=C2)=O)=C1
Technical Data
Additional Information
References
1: Lee K, Kang JE, Park SK, Jin Y, Chung KS, Kim HM,Lee K, Kang MR, Lee MK, Song KB, Yang EG, Lee JJ, Won M. LW6, a novelHIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha viaupregulation of VHL in a colon cancer cell line. Biochem Pharmacol. 2010Oct 1;80(7):982-9. Epub 2010 Jun 23. PubMed PMID: 20599784.
2: Liu XY, Wang BJ, Jiang CY, Liu SJ. Ornithinimicrobium pekingense sp.nov., isolated from activated sludge. Int J Syst Evol Microbiol. 2008Jan;58(Pt 1):116-9. PubMed PMID: 18175694.
3: Whitehead L. Toward a trajectory of identity reconstruction inchronic fatigue syndrome/myalgic encephalomyelitis: a longitudinalqualitative study. Int J Nurs Stud. 2006 Nov;43(8):1023-31. Epub 2006Mar 9. PubMed PMID: 16527282.
4: Whitehead LC. Quest, chaos and restitution: living with chronicfatigue syndrome/myalgic encephalomyelitis. Soc Sci Med. 2006May;62(9):2236-45. Epub 2005 Oct 19. PubMed PMID: 16236413.
