Chloro-SU5416featured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406219
CAS#:1055412-47-9 (Chloro-SU5416)
Description:Chloro-SU5416, also known as Chloro-Semaxanib,is a potent and selective FLT3 inhibitor and RET inhibitor. Chloro-Semaxanib is a derivative ofSemaxanib with a chloro atom at 5-position.Chloro-SU5416 has inhibitory activity for FLT3 and selectively induces growth arrest, apoptosis, and cell cycle arrest in Ba/F3 and AML cell lines expressing a constitutively activated FLT3.
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Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406219Name: Chloro-SU5416CAS#: 1055412-47-9 (Chloro-SU5416)Chemical Formula: C15H13ClN2OExact Mass: 272.07164Molecular Weight: 272.73Elemental Analysis: C, 66.06; H, 4.80; Cl, 13.00; N, 10.27; O, 5.87
Related CAS #:Semaxanib HCl204005-46-9 (free base)1055412-47-9 (Chloro-SU5416)
Synonym:Chloro-SU5416; Chloro-SU-5416; Chloro-SU 5416 Sugen 5416; Chloro-semoxind; Chloro-Semaxanib;
IUPAC/Chemical Name:(3Z)-5-Chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
InChi Key:XLBQNZICMYZIQT-GHXNOFRVSA-N
InChi Code:InChI=1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)/b12-7-
SMILES Code:O=C1NC2=C(C=C(Cl)C=C2)/C1=C/C3=C(C)C=C(C)N3
Technical Data
Additional Information
References
1: Arseni N, Ahmed F, Hiddemann W, Buske C,Feuring-Buske M. Effects of the protein tyrosine kinase inhibitor,SU5614, on leukemic and normal stem cells. Haematologica. 2005Nov;90(11):1577-8. PubMed PMID: 16266907.
2: Aleskog A, Höglund M, Pettersson J, Hermansson M, Larsson R,Lindhagen E. In vitro activity of the flt3-inhibitor su5614 and standardcytotoxic agents in tumour cells from patients with wild type andmutated flt3 acute myeloid leukaemia. Leuk Res. 2005 Sep;29(9):1079-81.Epub 2005 Apr 15. PubMed PMID: 16038735.
3: Spiekermann K, Dirschinger RJ, Schwab R, Bagrintseva K, Faber F,Buske C, Schnittger S, Kelly LM, Gilliland DG, Hiddemann W. The proteintyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrestand apoptosis in AML-derived cell lines expressing a constitutivelyactivated FLT3. Blood. 2003 Feb 15;101(4):1494-504. Epub 2002 Oct 24.PubMed PMID: 12406902.
4: Yee KW, O"Farrell AM, Smolich BD, Cherrington JM, McMahon G, Wait CL,McGreevey LS, Griffith DJ, Heinrich MC. SU5416 and SU5614 inhibit kinaseactivity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood.2002 Oct 15;100(8):2941-9. PubMed PMID: 12351406.
5: Spiekermann K, Faber F, Voswinckel R, Hiddemann W. The proteintyrosine kinase inhibitor SU5614 inhibits VEGF-induced endothelial cellsprouting and induces growth arrest and apoptosis by inhibition of c-kitin AML cells. Exp Hematol. 2002 Jul;30(7):767-73. PubMed PMID: 12135675.
