CGP52421

WARNING: This product is for research use only, not for human or veterinary use.

Description:CGP52421 is a FLT3 inhibitor, which is also an metabolite of midostaurin (PKC412).

Price and Availability

CGP52421, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406204Name: CGP52421CAS#: 179237-49-1Chemical Formula: C36H32N4O5Exact Mass: 600.23727Molecular Weight: 600.66Elemental Analysis: C, 71.98; H, 5.37; N, 9.33; O, 13.32

Synonym:CGP52421; CGP-52421; CGP 52421.

IUPAC/Chemical Name:N-((5S,7S,8S,10R)-15-hydroxy-8-methoxy-10-methyl-17-oxo-6,7,8,9,10,15,16,17-octahydro-5H-18-oxa-4b,10a,16-triaza-5,10-methanodibenzo[b,h]cyclodeca[jkl]cyclopenta[e]-as-indacen-7-yl)-N-methylbenzamide

InChi Key:WMQSFYBLPAXEDG-VPROBEFOSA-N

InChi Code:InChI=1S/C36H32N4O5/c1-36-18-25(44-3)24(38(2)35(43)19-11-5-4-6-12-19)17-26(45-36)39-22-15-9-7-13-20(22)27-29-30(34(42)37-33(29)41)28-21-14-8-10-16-23(21)40(36)32(28)31(27)39/h4-16,24-26,34,42H,17-18H2,1-3H3,(H,37,41)/t24-,25-,26-,34?,36+/m0/s1

SMILES Code:O=C(N([C@H]1C[C@@](O2)([H])N3C4=CC=CC=C4C5=C3C6=C(C7=CC=CC=C7N6[C@@]2(C)C[C@@H]1OC)C(C(O)N8)=C5C8=O)C)C9=CC=CC=C9

Technical Data

Additional Information

References

1: Yin OQ, Wang Y, Schran H. A mechanism-basedpopulation pharmacokinetic model for characterizing time-dependentpharmacokinetics of midostaurin and its metabolites in human subjects.Clin Pharmacokinet. 2008;47(12):807-16. doi:10.2165/0003088-200847120-00005. PubMed PMID: 19026036.

2: Wang Y, Yin OQ, Graf P, Kisicki JC, Schran H. Dose- andtime-dependent pharmacokinetics of midostaurin in patients with diabetesmellitus. J Clin Pharmacol. 2008 Jun;48(6):763-75. doi:10.1177/0091270008318006. PubMed PMID: 18508951.

3: Illmer T, Thiede HM, Thiede C, Bornhäuser M, Schaich M, Schleyer E,Ehninger G. A highly sensitive method for the detection of PKC412(CGP41251) and its metabolites by high-performance liquidchromatography. J Pharmacol Toxicol Methods. 2007 Jul-Aug;56(1):23-7.Epub 2007 Feb 23. PubMed PMID: 17395497.

4: Levis M, Brown P, Smith BD, Stine A, Pham R, Stone R, Deangelo D,Galinsky I, Giles F, Estey E, Kantarjian H, Cohen P, Wang Y, Roesel J,Karp JE, Small D. Plasma inhibitory activity (PIA): a pharmacodynamicassay reveals insights into the basis for cytotoxic response to FLT3inhibitors. Blood. 2006 Nov 15;108(10):3477-83. Epub 2006 Jul 20. PubMedPMID: 16857987; PubMed Central PMCID: PMC1895426.