AZD-2932featured
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:401120
CAS#:883986-34-3
Description:AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR. AZD-2932 has a balanced ~ 1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes, respectively. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases. The pharmacokinetic behavior and the preclinical antitumor activity in nude mice bearing C6 rat glial tumors indicate that 31 has the potential to become an antiangiogenic agent in the clinic.
Price and Availability
AZD-2932, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 401120Name: AZD-2932CAS#: 883986-34-3Chemical Formula: C24H25N5O4Exact Mass: 447.19065Molecular Weight: 447.49Elemental Analysis: C, 64.42; H, 5.63; N, 15.65; O, 14.30
Synonym:AZD2932; AZD 2932; AZD-2932
IUPAC/Chemical Name:2-(4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-N-(1-isopropyl-1H-pyrazol-4-yl)acetamide
InChi Key:TWYCZJMOEMMCGC-UHFFFAOYSA-N
InChi Code:InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
SMILES Code:O=C(NC1=CN(C(C)C)N=C1)CC2=CC=C(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)C=C2
Technical Data
Additional Information
References
1: Plé PA, Jung F, Ashton S, Hennequin L, Laine R,Morgentin R, Pasquet G, Taylor S. Discovery of AZD2932, a newQuinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFRtyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. doi:10.1016/j.bmcl.2011.11.019. Epub 2011 Nov 12. PubMed PMID: 22153662.
