ATH686

WARNING: This product is for research use only, not for human or veterinary use.

Description:ATH686 is a FLT3 inhibitor.

Price and Availability

ATH686,is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406218Name: ATH686CAS#: NONEChemical Formula: C25H28F3N7O2Exact Mass: 515.22566Molecular Weight: 515.53Elemental Analysis: C, 58.24; H, 5.47; F, 11.06; N, 19.02; O, 6.21

Synonym:ATH686; ATH 686; ATH-686

IUPAC/Chemical Name:1-(4-((2-aminopyrimidin-4-yl)oxy)phenyl)-3-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)urea

InChi Key:VQQRBBFRJRBWPF-UHFFFAOYSA-N

InChi Code:InChI=1S/C25H28F3N7O2/c1-2-34-11-13-35(14-12-34)16-17-3-4-19(15-21(17)25(26,27)28)32-24(36)31-18-5-7-20(8-6-18)37-22-9-10-30-23(29)33-22/h3-10,15H,2,11-14,16H2,1H3,(H2,29,30,33)(H2,31,32,36)

SMILES Code:O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)NC3=CC=C(OC4=NC(N)=NC=C4)C=C3

Technical Data

Additional Information

References

1: Weisberg E, Roesel J, Furet P, Bold G, Imbach P,Flörsheimer A, Caravatti G, Jiang J, Manley P, Ray A, Griffin JD.Antileukemic Effects of Novel First- and Second-Generation FLT3Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010Oct;1(10):1021-32. doi: 10.1177/1947601910396505. PubMed PMID: 21779428;PubMed Central PMCID: PMC3092267.