AFG206

WARNING: This product is for research use only, not for human or veterinary use.

Description:AFG206 is the novel first-generation "type II" FLT3 inhibitor.

Price and Availability

AFG206, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406214Name: AFG206CAS#: 630122-37-1Chemical Formula: C20H19N3O2Exact Mass: 333.14773Molecular Weight: 333.38Elemental Analysis: C, 72.05; H, 5.74; N, 12.60; O, 9.60

Synonym:AFG206; AFG 206; AFG-206.

IUPAC/Chemical Name:1-(4-ethylphenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea

InChi Key:UUJSPHQATNSVLQ-UHFFFAOYSA-N

InChi Code:InChI=1S/C20H19N3O2/c1-2-15-3-5-16(6-4-15)22-20(24)23-17-7-9-18(10-8-17)25-19-11-13-21-14-12-19/h3-14H,2H2,1H3,(H2,22,23,24)

SMILES Code:O=C(NC1=CC=C(OC2=CC=NC=C2)C=C1)NC3=CC=C(CC)C=C3

Technical Data

Additional Information

References

1:  Ellen Weisberg, Johannes Roesel, PascalFuret, Guido Bold, Patricia Imbach, Andreas Flörsheimer, GeorgioCaravatti, Jingrui Jiang, Paul Manley, Arghya Ray, James D. Griffin.Antileukemic Effects of Novel First- and Second-Generation FLT3Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 October;1(10): 1021–1032. doi: 10.1177/1947601910396505 PMCID: PMC3092267