FIIN-1

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WARNING: This product is for research use only, not for human or veterinary use.

Description:FIIN-1 is Potent, irreversible FGFR inhibitor, acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2.

Price and Availability

FIIN-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406108Name: FIIN-1CAS#: 1256152-35-8Chemical Formula: C32H39Cl2N7O4Exact Mass: 655.24406Molecular Weight: 656.6Elemental Analysis: C, 58.54; H, 5.99; Cl, 10.80; N, 14.93; O, 9.75

Synonym:FIIN1; FIIN-1; FIIN 1

IUPAC/Chemical Name:N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4- dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide

InChi Key:DNVFTXQYIYFQBW-UHFFFAOYSA-N

InChi Code:InChI=1S/C32H39Cl2N7O4/c1-6-26(42)37-23-13-11-12-21(16-23)19-41-30-22(18-36-31(38-30)35-14-9-10-15-39(7-2)8-3)20-40(32(41)43)29-27(33)24(44-4)17-25(45-5)28(29)34/h6,11-13,16-18H,1,7-10,14-15,19-20H2,2-5H3,(H,37,42)(H,35,36,38)

SMILES Code:C=CC(NC1=CC=CC(CN(C2=NC(NCCCCN(CC)CC)=NC=C2CN3C4=C(Cl)C(OC)=CC(OC)=C4Cl)C3=O)=C1)=O

Technical Data

Additional Information

References

 1: Zhou W, Hur W, McDermott U, Dutt A, Xian W,Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, GrayNS. A structure-guided approach to creating covalent FGFR inhibitors.Chem Biol. 2010 Mar 26;17(3):285-95. doi:10.1016/j.chembiol.2010.02.007. PubMed PMID: 20338520; PubMed CentralPMCID: PMC2920453.