PND-1186

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WARNING: This product is for research use only, not for human or veterinary use.

Description:PND-1186, also known as SR-2156 and VS-4718, is a potent FAK inhibitor with a 50% inhibitory concentration (IC50) of 1.5 nM in vitro. PND-1186 has an IC50 of ~100 nM in breast carcinoma cells. Notably, 1.0 µM PND-1186 (>5-fold above IC50) had limited effects on cell proliferation. However, under non-adherent conditions as spheroids and as colonies in soft agar, 0.1 µM PND-1186 blocked FAK and p130Cas tyrosine phosphorylation, promoted caspase-3 activation, and triggered cell apoptosis. PND-1186 inhibited 4T1 breast carcinoma subcutaneous tumor growth correlated with elevated tumor cell apoptosis and caspase 3 activation.

Price and Availability

PND-1186, purity > 98%, is in stock. The same day shipping out after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406262Name: PND-1186CAS#: 1061353-68-1Chemical Formula: C25H26F3N5O3Exact Mass: 501.19877Molecular Weight: 501.5Elemental Analysis: C, 59.87; H, 5.23; F, 11.36; N, 13.96; O, 9.57

Synonym:PND1186; PND 1186; PND1186; SR 2516; SR2516; SR2516; VS4718; VS4718; VS 4718.

IUPAC/Chemical Name:2-((2-((2-methoxy-4-morpholinophenyl)amino)-5-(trifluoromethyl)pyridin-4-yl)amino)-N-methylbenzamide.

InChi Key:IGUBBWJDMLCRIK-UHFFFAOYSA-N

InChi Code:InChI=1S/C25H26F3N5O3/c1-29-24(34)17-5-3-4-6-19(17)31-21-14-23(30-15-18(21)25(26,27)28)32-20-8-7-16(13-22(20)35-2)33-9-11-36-12-10-33/h3-8,13-15H,9-12H2,1-2H3,(H,29,34)(H2,30,31,32)

SMILES Code:O=C(NC)C1=CC=CC=C1NC2=CC(NC3=C(OC)C=C(N4CCOCC4)C=C3)=NC=C2C(F)(F)F

Technical Data

Additional Information

References

1: Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, LawsonC, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD. FAK Inhibitiondisrupts a β5 integrin signaling axis  controllinganchorage-independent ovarian carcinoma growth. Mol Cancer Ther. 2014Aug;13(8):2050-61. doi: 10.1158/1535-7163.MCT-13-1063. Epub 2014 Jun 4.PubMed PMID: 24899686; PubMed Central PMCID: PMC4126870.