QL47
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406460
CAS#:1469988-75-7
Description:QL47, also known as QL-XII-47, is a potent and selective BTK inhibitor, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations.
Price and Availability
QL47is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406460Name: QL47CAS#: 1469988-75-7Chemical Formula: C27H21N5O2Exact Mass: 447.16952Molecular Weight: 447.48794Elemental Analysis: C, 72.47; H, 4.73; N, 15.65; O, 7.15
Synonym:QL47; QL 47; QL47. QL-XII-47
IUPAC/Chemical Name:1-(1-acryloylindolin-6-yl)-9-(1-methyl-1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2(1H)-one
InChi Key:RTRNJQOBEOISFQ-UHFFFAOYSA-N
InChi Code:InChI=1S/C27H21N5O2/c1-3-25(33)31-11-10-17-4-7-21(13-24(17)31)32-26(34)9-6-19-14-28-23-8-5-18(12-22(23)27(19)32)20-15-29-30(2)16-20/h3-9,12-16H,1,10-11H2,2H3
SMILES Code:O=C1N(C2=CC3=C(C=C2)CCN3C(C=C)=O)C4=C(C=NC5=CC=C(C6=CN(C)N=C6)C=C54)C=C1
Technical Data
Additional Information
References
1: Wu H, Wang W, Liu F, Weisberg EE, Tian B, Chen Y,Li B, Wang A, Wang B, Zhao Z, McMillin DW, Hu C, Li H, Wang J, Liang Y,Buhrlage SJ, Liang J, Liu J, Yang G, Brwon JR, Treon SP, Mitsiades CS,Griffin J, Liu Q, Gray NS. Discovery of a Potent, Covalent BTK Inhibitorfor B-Cell Lymphoma. ACS Chem Biol. 2014 Feb 20. [Epub ahead of print]PubMed PMID: 24556163.
