META060
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406283
CAS#:unknown
Description:META060 is multikinase inhibitor, which inhibits the activity of kinases (spleen tyrosine kinase, Bruton's tyrosine kinase, phosphatidylinositol 3-kinase, and GSK3) associated with RA and inhibits beta-catenin phosphorylation. META060 also inhibits osteoclastogenesis as wells as inhibits IL-1beta-activated prostaglandin E(2), matrix metalloproteinase 3, IL-6, IL-8, and monocyte chemotactic protein 1 in RASFs. In mice with acute inflammation, oral administration of META060 reduced paw swelling similar to the effect of aspirin. In mice with CIA, META060 significantly reduced the arthritis index and decreased bone, joint, and cartilage degradation. Serum IL-6 concentrations in these mice were inhibited in a dose-dependent manner. META060 may have therapeutic potential in the treatment of inflammatory diseases. (Arthritis Rheum. 2010 Jun;62(6):1683-92 )
Price and Availability
META060 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406283Name: META060CAS#: unknownChemical Formula: Exact Mass: Molecular Weight: Elemental Analysis:
Synonym:META-060; META060; META 060
IUPAC/Chemical Name:Unknown
Technical Data
Additional Information
References
1: Vroegrijk IO, van Diepen JA, van den Berg SA,Romijn JA, Havekes LM, van Dijk KW, Darland G, Konda V, Tripp ML, BlandJS, Voshol PJ. META060 protects against diet-induced obesity and insulinresistance in a high-fat-diet fed mouse. Nutrition. 2013Jan;29(1):276-83. doi: 10.1016/j.nut.2012.05.004. Epub 2012 Sep 15.PubMed PMID: 22985971.
2: Desai A, Darland G, Bland JS, Tripp ML, Konda VR. META060 attenuatesTNF-α-activated inflammation, endothelial-monocyte interactions, andmatrix metalloproteinase-9 expression, and inhibits NF-κB and AP-1 inTHP-1 monocytes. Atherosclerosis. 2012 Jul;223(1):130-6. doi:10.1016/j.atherosclerosis.2012.05.004. Epub 2012 May 15. PubMed PMID:22658256.
3: Everard A, Geurts L, Van Roye M, Delzenne NM, Cani PD. Tetrahydro iso-alphaacids from hops improve glucose homeostasis and reduce body weight gainand metabolic endotoxemia in high-fat diet-fed mice. PLoS One.2012;7(3):e33858. doi: 10.1371/journal.pone.0033858. Epub 2012 Mar 28.PubMed PMID: 22470484; PubMed Central PMCID: PMC3314685.
4: Konda VR, Desai A, Darland G, Bland JS, Tripp ML. META060 inhibitsosteoclastogenesis and matrix metalloproteinases in vitro and reducesbone and cartilage degradation in a mouse model of rheumatoid arthritis.Arthritis Rheum. 2010 Jun;62(6):1683-92. doi: 10.1002/art.27441. PubMedPMID: 20201075.
5: Desai A, Konda VR, Darland G, Austin M, Prabhu KS, Bland JS, CarrollBJ, Tripp ML. META060 inhibits multiple kinases in the NF-kappaB pathwayand suppresses LPS--mediated inflammation in vitro and ex vivo. InflammRes. 2009 May;58(5):229-34. doi: 10.1007/s00011-008-8162-y. PubMed PMID:19169645.
