NVP-BHG712

featured

WARNING: This product is for research use only, not for human or veterinary use.

Description:NVP-BHG712, also known as BHG-712, is a EphB4 kinase inhibitor and BCR-ABL inhibitor. NVP-BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays.BHG-712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration.

Price and Availability

NVP-BHG712, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 406172Name: NVP-BHG712CAS#: 940310-85-0Chemical Formula: C26H20F3N7OExact Mass: 503.16814Molecular Weight: 503.48Elemental Analysis: C, 62.02; H, 4.00; F, 11.32; N, 19.47; O, 3.18

Synonym:NVP BHG712; NVP BHG-712; NVP BHG 712; BHG-712; BHG712; BHG 712.

IUPAC/Chemical Name:4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide

InChi Key:ZCCPLJOKGAACRT-UHFFFAOYSA-N

InChi Code:InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35)

SMILES Code:O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(NC3=C4C(N(C)N=C4)=NC(C5=CC=CN=C5)=N3)=C2

Technical Data

Additional Information

References

1: Wnuk M, Hlushchuk R, Janot M, Tuffin G, Martiny-BaronG, Holzer P, Imbach-Weese P, Djonov V, Huynh-Do U. Podocyte EphB4signaling helps recovery from glomerular injury. Kidney Int. 2012Jun;81(12):1212-25. doi: 10.1038/ki.2012.17. Epub 2012 Mar 7. PubMedPMID: 22398409.