BIIB028
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:204676
CAS#:911398-13-5 (free acid)
Description:BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses.
Price and Availability
BIIB028 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 204676Name: BIIB028CAS#: 911398-13-5 (free acid)Chemical Formula: C19H21ClN5O5PExact Mass: 465.0969Molecular Weight: 465.8308Elemental Analysis: C, 48.99; H, 4.54; Cl, 7.61; N, 15.03; O, 17.17; P, 6.65
Related CAS #:911398-12-4 (sodium)911398-13-5 (free acid)
Synonym:BIIB028; BIIB 028; BIIB-028.
IUPAC/Chemical Name:4-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)but-3-yn-1-yl dihydrogen phosphate
InChi Key:BMZGPNGECPQAGB-UHFFFAOYSA-N
InChi Code:InChI=1S/C19H21ClN5O5P/c1-11-8-22-14(12(2)16(11)29-3)10-25-9-13(6-4-5-7-30-31(26,27)28)15-17(20)23-19(21)24-18(15)25/h8-9H,5,7,10H2,1-3H3,(H2,21,23,24)(H2,26,27,28)
SMILES Code:CC1=CN=C(CN2C=C(C#CCCOP(O)(O)=O)C3=C(Cl)N=C(N)N=C32)C(C)=C1OC
