AP23848
WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#:406171
CAS#:834894-21-2
Description:AP23848 is a potent Bcr-Abl inhibitor. In a murine model, AP23848 inhibited activation-loop mutant Kit phosphorylation and tumor growth.
Price and Availability
AP23848, purity > 98%,is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.
Chemical Structure
Theoretical Analysis
MedKoo Cat#: 406171Name: AP23848CAS#: 834894-21-2Chemical Formula: C30H38N5O2PExact Mass: 531.27631Molecular Weight: 531.63Elemental Analysis: C, 67.78; H, 7.20; N, 13.17; O, 6.02; P, 5.83
Synonym:AP23848; AP-23848; AP 23848.
IUPAC/Chemical Name:(4-((2-cyclopentyl-9-(3-hydroxyphenethyl)-9H-purin-6-yl)amino)phenyl)dipropylphosphine oxide
InChi Key:VTPNIONIOLOGFM-UHFFFAOYSA-N
InChi Code:InChI=1S/C30H38N5O2P/c1-3-18-38(37,19-4-2)26-14-12-24(13-15-26)32-29-27-30(34-28(33-29)23-9-5-6-10-23)35(21-31-27)17-16-22-8-7-11-25(36)20-22/h7-8,11-15,20-21,23,36H,3-6,9-10,16-19H2,1-2H3,(H,32,33,34)
SMILES Code:CCCP(CCC)(C1=CC=C(NC2=C3N=CN(CCC4=CC=CC(O)=C4)C3=NC(C5CCCC5)=N2)C=C1)=O
Technical Data
Additional Information
References
1: O"Hare T, Walters DK, Stoffregen EP,Sherbenou DW, Heinrich MC, Deininger MW,Druker BJ. Combined Abl inhibitor therapy for minimizing drug resistancein chronic myeloid leukemia: Src/Abl inhibitors are compatible withimatinib. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6987-93. PubMed PMID: 16203792.
2: Corbin AS, Demehri S, Griswold IJ, Wang Y, Metcalf CA 3rd,Sundaramoorthi R, Shakespeare WC, Snodgrass J, Wardwell S, Dalgarno D, Iuliucci J, SawyerTK, Heinrich MC, Druker BJ, Deininger MW. In vitro and in vivo activity ofATP-basedkinase inhibitors AP23464 and AP23848 against activation-loop mutants ofKit. Blood. 2005 Jul 1;106(1):227-34. Epub 2005 Mar 3. PubMed PMID: 15746079.
