MedKooCat#:510258
Name:GNE-0877
CAS#:1374828-69-9
ChemicalFormula:C14H16F3N7
ExactMass:339.14193
MolecularWeight:339.31895
ElementalAnalysis:C,49.56;H,4.75;F,16.80;N,28.90
Synonym:GNE0877;GNE0877;GNE-0877.
IUPAC/ChemicalName:2-methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile.
InChiKey:ZPPUMAMZIMPJGP-UHFFFAOYSA-N
InChiCode:InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
SMILESCode:CC(N1N=C(C)C(NC2=NC=C(C(F)(F)F)C(NC)=N2)=C1)(C)C#N
TechnicalData
AdditionalInformation
References
1:EstradaAA,ChanBK,Baker-GlennC,BeresfordA,BurdickDJ,ChambersM,ChenH,DominguezSL,DotsonJ,DrummondJ,FlagellaM,FujiR,GillA,HalladayJ,HarrisSF,HeffronTP,KleinheinzT,LeeDW,PichonCE,LiuX,LyssikatosJP,MedhurstAD,MoffatJG,NashK,Scearce-LevieK,ShengZ,ShoreDG,WongS,ZhangS,ZhangX,ZhuH,SweeneyZK.DiscoveryofHighlyPotent,Selective,andBrain-PenetrantAminopyrazoleLeucine-RichRepeatKinase2(LRRK2)SmallMoleculeInhibitors.JMedChem.2014Jan15.[Epubaheadofprint]PubMedPMID:24354345.
